Physicochemical Studies of Human Ceruloplasmin
نویسندگان
چکیده
منابع مشابه
Physicochemical Studies on Human Plasminogen
Plasminogen (profibrinolysin) of high specific activity has been prepared from human sources and converted to plasmin (fibrinolysin) by a variety of means (3, 4). Since these preparations seemed to possess activities of as high an order as any that had yet been produced, it was considered appropriate to examine their purity by physicochemical means. Such investigations do not appear to have bee...
متن کاملStudies of Human Ceruloplasmin Fractions Separated by Chromatography on Hydroxylapatite.
Recent physicochemical(l,2) and immunochemical(3) studies from our laboratory have shown that human ceruloplasmin is a labile protein the properties of which are readily modified by a variety of experimental conditions. Our previous data, however, indicated that crystalline ceruloplasmin was a single protein. This is at variance with results from other laboratories which have shown that chromat...
متن کاملImmunochemical studies of crystalline human ceruloplasmin and derivatives.
Previous immunochemical investigations of ceruloplasmin have been primarily concerned with the assay of this substance in human sera and its localization by the technique of immunoelectrophoresis. The proteins used in the preparation of antisera appear to have been impure or poorly defined. The ready availability of crystalline human ceruloplasmin (I, 2) prompted us to study its immunochemical ...
متن کاملPhysical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo.
Injection into rabbits of radioactive ceruloplasmin from which sialic acid had been removed enzymatically resulted in a rapid disappearance of the asialoceruloplasmin from the seruni and its appearance in parenchymal cells, but not in Kupffer cells, of the liver. The rapidity of this transfer was dependent upon the presence of intact galactose residues as the terminal, nonreducing sugar of the ...
متن کاملinhibition of human ceruloplasmin (ferroxidase) by cadmium
ceruloplasmin (cp) is a human plasma protein with multiple physiological functions including ferroxidase and oxidase activities. deficiency or inhibition of the enzyme may lead to some abnormalities, including iron deposition in several tissues and causes various pathological conditions in the body. direct interaction of cadmium (cd), a widespread, highly toxic environmental pollutant, with hum...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1963
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)67973-1